Dysport

The Center for Laser Surgery is the only Washington, DC practice selected to perform the FDA Stage III Clinical Trials for Dysport, a neurotoxin similar to the popular Botox Cosmetic®. As Washington, DC, Maryland, and Virginia's largest and most experienced Botox practice we were honored to be the sole Dysport investigator in Washington, DC. Dysport was FDA approved for cosmetic use on April 30, 2009, and is the first competing neurotoxin available alongside the widely available Botox Cosmetic®.

What is Dysport?


Dysport is a simple, effective, non-surgical treatment that works by relaxing facial muscles, thereby reducing and smoothing away frown-lines and wrinkles. Dysport, like Botox Cosmetic® is a protein extracted from the bacterium Clostridium Botulinum. The Dysport protein was initially used for the treatment of motor disorders and various kinds of involuntary muscular spasms, including cerebral palsy.

Dysport was originally to be licensed in the United States under the brand name Reloxin. Most articles pertaining to this drug in the United States referred to it as Reloxin. The FDA mandated that the drug be branded under its original name, Dysport (rather than Reloxin) prior to its April 2009 FDA approval.

Is Dysport New?


NO! Dysport has been available in Europe, Asia, and South America for over 10 years. Dysport is manufactured by Ipsen Pharmaceuticals (FRA) and is supported by over a decade of clinical experience. Dysport is distributed in the United States by Medicis, the manufacturers of the revolutionary Restylane dermal filler. Dysport was developed in the United Kingdom in the early 1990s to successfully treat a number of neurological and ophthalmic conditions. It was further developed to treat a wide variety of neuromuscular disorders, for which it is licensed in over 60 countries. Since that time, with an increased understanding of the uses of Dysport, thousands of treatments have been safely and effectively performed for a variety of conditions ranging from facial wrinkles to axillary hyperhidrosis (excessive sweating under the armpits).

Is Dysport Better Than Botox?


This topic is widely debated and heavily biased due to most comparative cosmetic studies being partially or fully funded by manufacturers of Botox (Allergan) and Dysport (Ipsen/Medicis). Many cosmetic physicians outside the U.S. who have used Dysport report greater longevity when compared to Botox. In most unbiased neurological studies for the treatment of movement disorders Dysport has provided equal or greater efficacy when used in a 2.5 to 4:1 ratio to Botox. In a double-blinded randomized crossover study in cervical dystonia (the most common use of neurotoxin in the world), results showed Dysport to be more effective than Botox with a similar safety and side effect profile when used in a 3:1 dose relationship.

Why is Injector Selection More Important Than Ever?


Studies indicate that Dysport possibly disperses more widely than Botox Cosmetic when injected. While this is advantageous when treating broader areas of small wrinkles such as crows feet, when used to treat glabellar lines of the forehead it could lead to increased occurrence of ptosis (drooping eyelid) if injected by someone inexperienced with Dysport. As Washington DC’s largest Cosmetic Injectable Practice and the only area Practice to perform the FDA Clinical Trials for Dysport the Center for Laser Surgery has the most experience using Dysport in the Washington, DC, Maryland, and Virginia areas.

Center for Laser Surgery Independent Study


In addition to performing the FDA Stage III Clinical Trials at our Washington, DC location, in 2006 the Center for Laser Surgery sponsored and fully funded a 24-patient double blinded comparative study of Dysport and Botox in the treatment of forehead lines in Karlsruhe, Germany. The results of this study, both physical observation and patient feedback, indicated that Dysport was faster acting and longer lasting than Botox when used in a 3:1 unit ratio to Botox.

How does Dysport work?


Dysport blocks impulses from the nerve to the facial muscles that are related to expression lines. Dysport relaxes the muscles so they do not contract. After treatment, the overlying skin becomes smooth and unwrinkled, while the untreated facial muscles contract in a normal fashion, allowing normal facial expression to be unaffected.

How is Dysport used?


Tiny amounts of Dysport are injected directly into the facial muscles underlying the frown lines. It usually takes three to five small, almost painless injections between the eyebrows for an effective treatment. No local anesthetic is usually required but if you are concerned a numbing cream can be applied prior to treatment. Treatment is normally over in less than 15 minutes. Over the next few days, the muscles gradually relax allowing wrinkles to loosen and skin in the treated area to appear more youthful.

Is Dysport Safe?


Dysport injections have been used safely and effectively for over fifteen years to treat many ophthalmologic and neurological disorders. Numerous safety studies performed in around the world have shown it to have an equal or more favorable safety profile than Botox. However, while rare some side effects can and occur. The most common side effects are temporary soreness or mild bruising around the injection site. Some people may experience a slight headache that lasts for several hours after treatment; it is safe to take a mild pain killer to relieve this. In a very small percentage of cases there can be a complication called "ptosis" (a drooping eyelid) which may last a few days or up to 4 weeks. Ptosis is not considered to be a normal side effect and is normally due to injector error or lack of injector experience.




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